North Callaway scored 36 unanswered points to roll past Mark Twain 46-8.
After not scoring in the first half, Palmyra held Macon scoreless in the second half for a 22-8 victory.
Monroe City was shut out 42-0 in Clarence Cannon Conference action.
The Hannibal senior linebacker was responsible for three total touchdowns as the Pirates thumped Marshall 63-15.
Game info for Marshall at Hannibal.
Running back Damien French has rushed for more than 200 yards in the last three games, all Hannibal victories.
Clark County seemed to have an answer for everything Palmyra did, beating the Panthers 38-24.
Hannibal rallied from a halftime deficit to beat Moberly for its fourth straight victory.
Helias scored five touchdowns after halftime to roll over Monroe City.
The Mark Twain football team didn't score in the second half but held on to beat Clopton.